What have the drugs you are eating done to your kidneys

Kidney is the main excretory organs, it is a regulation organs at the same time, through the secretion of hormone kind material to adjust the body's metabolism, the integrity of the renal function is closely related to the environmental balance in body, kidney in metabolism, waste discharge, and components of extracellular fluid volume adjustment, electrolyte and acid-base balance plays a very important role.
Kidney also synthesize and release hormones and active substances. Drug damage will result in the damaged kidneys, and has a serious effect on whole body metabolism.
Renal toxicity of clinical manifestations of weight is differ, the earliest symptoms for proteinuria and urine tube type, which in turn can happen n qualitative hematic disease, renal impairment, serious when can appear acute renal failure and uremia. Available for transient renal toxicity, can also be used for permanent damage. Common drugs can cause renal toxicity has certain antibacterial, antitumor drug, antipyretic analgesic anti-inflammatory drug, drug, iodide contrast agents, lithium carbonate and triamterene, etc.
1. direct renal toxicity of a variety of drugs in blood into the renal filtration and could easily be concentration, concentration of renal tissues significantly higher than that of other organs, especially the malpighian tube and the concentration of the renal tubules surrounding more than other groups. Therefore, renal tubular cells
Contact with the concentration of the drug is higher than other cells. High metabolic activity of renal tubular cells, increased renal tubular damage susceptibility to drugs, getting the drug to the kidney injury often results in changes in the structure and function of renal tubules. All kinds of drugs through different mechanisms of injury kidney, its strength depends on the length of contact the concentration of the drug, sustained and kidney drug susceptibility and resistance factors.
2. lead to damage to the kidneys and kidney ischemia drugs in addition to direct effects on the kidney cells, also related to the drug-induced renal ischemia, interaction between them.
3. immune inflammatory reaction of certain drugs and its degradation products with the host protein (protein), renal tubule and renal interstitial interaction, change the structure of host proteins, making it a hapten and antigen, induction of antibodies and antigen antibody complex formation, deposition in the glomerular capillary basement membrane and small arteries in the basal membrane. Moreover, necrosis of renal tubule epithelial cells may also be antigen, the autoantibodies to form, also can through the antigen antibody complex mechanisms that lead to renal tubule and renal interstitial lesions.
4 some drug deposition clog renal tubules obstructive nephropathy, calyces and renal pelvis or ureter, can cause the crystals nephropathy, acute obstructed kidney damage caused by urinary tract obstruction, renal tubular epithelial cells degeneration and necrosis accompanied by renal interstitial cells infiltrating