Why high blood pressure with diabetes mellitus can cause kidney damage

Ms, 48 years old, too fat. Type 2 diabetes for many years, unstable blood glucose, blood pressure is high low, irregular medication. Physical examination findings: retinal arteriolar moderate stenosis, belongs to the fundus change Ⅱ level high blood pressure. Serum creatinine and 24 hour albumin increased, belongs to the diabetic nephropathy Ⅱ period.
About 20% of the patients with type 2 diabetes will merge kidney disease. Should attach great importance to the examination of renal function. Creatinine and proteinuria is important indicator of renal function, blood biochemical and can in routine urine examination. Serum creatinine and albuminuria than ms results suggest she has mild renal damage, now is still in the stage of could be reversed, as long as active treatment, can be restored.
Ms wan mergers increased renal damage of hypertension. High blood pressure can make the renal artery blood wall harden, vascular stenosis, when only 30% of normal blood vessel diameter, can stimulate the body is secreted renin, excess causing the renin - angiotensin aldosterone system (RAAS), angiotensin Ⅱ is produced. A strong vasoconstrictor angiotensin Ⅱ role, enables the aldosterone secretion increased, thus reducing the kidney to discharge water, increase the blood volume, further raise blood pressure. Blood vessels are more narrow, renin hormones such as produce, the more the higher blood pressure levels, "the renin - angiotensin - - high blood pressure - aldosterone renin" a vicious cycle.
If condition can not get effective control, the vascular lumen stenosis, renal tissue ischemia oxygen for a long time, can appear kidney atrophy, cause your kidneys to lose normal function, eventually lead to renal failure, uremia. In patients with hypertension combined renal function damage, therefore, when choosing antihypertensive drugs, drugs should be considered whether a vicious circle caused by hormones such as renin has blocking effects.