What Causes Nephrotic syndrome

Nephrotic syndrome is caused by different disorders that damage the kidneys. This damage leads to the release of too much protein in the urine.
The most common cause in children is minimal change disease. Membranous glomerulonephritis is the most common cause in adults.
This condition can also occur from:
Cancer
Diseases such as diabetes, systemic lupus erythematosus, multiple myeloma, and amyloidosis
Genetic disorders
Immune disorders
Infections (such as strep throat, hepatitis, or mononucleosis)
Use of certain drugs
It can occur with kidney disorders such as:
Focal and segmental glomerulosclerosis
Glomerulonephritis
Mesangiocapillary glomerulonephritis
Nephrotic syndrome can affect all age groups. In children, it is most common between ages 2 and 6. This disorder occurs slightly more often in males than females.